Takao Shimizu, M.D. Ph.D.
Professor
Department of Biochemistry and Molecular Biology
Dean
Faculty of Medicine, The University of Tokyo
Bunkyo-ku, Tokyo 113-0033, Japan
Phone 81-3-5802-2925
Fax 81-3-3813-8732
e-mail: tshimizu@m.u-tokyo.ac.jp

Education:
1965-1968 Undergraduate, Faculty of Liberal Arts, The University of Tokyo
1968-1973 Undergraduate, Faculty of Medicine, The University of Tokyo
March 28, 1973 M.D.
1973-1975 Clinical Training in Internal Medicine, The University of Tokyo Hospital
1975-1977 Postgraduate research training in Biochemistry, Kyoto University
February 16, 1980 Ph. D. degree (Medical Science)

Professional Record:
1977-1982 Assistant Professor in Medical Chemistry , Kyoto University School of Medicine, Kyoto (Osamu Hayaishi)
1982-1984 Visiting Scientist at Department of Chemistry, Karolinska Institute, Stockholm (Bengt Samuelsson)
1984-1991 Associate Professor in Physiological Chemistry and Nutrition, Faculty of Medicine, The University of Tokyo
1991-Present Professor, Department of Biochemistry, Faculty of Medicine, The University of Tokyo
2003- Vice Dean of Faculty of Medicine, The University of Tokyo, Director of Institute for Disease Biology and Integrated Medicine, Faculty of Medicine, The University of Tokyo.
2004- Research advisor for the Ministry of Education, Culture, Sports, Science and Technology (MEXT) of Japan
2007- Dean, Faculty of Medicine

Award:
The Research Promotion Award from the Japanese Biochemical Society (1981)
Ermst Schering Prize, Germany (2000)
Prize from Japanese Medical Association (2000)
Mochida Award for Science and Technology, Japan (2001)
Takeda Medical Award , Japan (2003)
Uehara Memorial Award (2004)
Japan Academy Prize (2009)

Membership of Academy Society:
Japanese Biochemical Society
Japanese Society of Molecular Biology
Japanese Society of Neuroscience
Japanese Society of Inflammation
Foreign Member of Society for Neuroscience (U. S. A.)
Member of American Society of Biochemistry & Molecular Biology
Member of New York Academy of Science
Member of American Association for the Advancement of Science (AAAS)

Editor and Reviewer:
Editorial Board of the Journal of Biological Chemistry 1997-2001, 2003-2007, 2010-
Editor of FASEB Journal 1998-Present
Editorial Board of Genes to Cells 1998-Present
Ad hoc reviewer:
   Science, Nature, Nature Immunol., Eur. J. Biochem., Biochem. J., Cell, J. Neurosci., EMBO J.
Grant Committee of Human Frontier Science Program (1999-)

Research Interest:
Biosynthesis and Functions of Lipid Mediators (platelet-activating factor, leukotrienes, prostaglandins, lysophosphatidic acid, phospholipase A2)
Roles of lipid mediators in self-defense and neural functions

Selected list of publications since 1991.

1. Honda, Z., Nakamura, M., Miki, I., Minami, M., Watanabe, T., Seyama, Y., Okado, H., Toh, H., Ito K., Miyamoto, T., and Shimizu, T: Cloning by functional expression of guinea pig lung platelet activating factor (PAF) receptor. Nature 349 342-346 (1991)
2. Bito, H., Nakamura, M., Honda, Z., Izumi, T., Iwatsubo, T., Seyama, Y., Ogura, A., Kudo, H., and Shimizu, T: Platelet-activating factor (PAF) receptor in rat brain: PAF mobilizes intracellular Ca2+ in hippocampal neurons. Neuron 9 285-294 (1992)
3. Yokomizo, T., Izumi, T., Takahashi, T., Kasama, T., Kobayashi, Y., Sato, F., and Shimizu, T.: Enzymatic inactivation of leukotriene B4 by a novel enzyme found in the porcine kidney. Purification and properties of leukotriene B4 12-hydroxy-dehydrogenase. J. Biol. Chem. 268. 18128-18135 (1993)
4. Mutoh, H., Fukuda, T., Kitamoto, T., Masushige, S., Sasaki, H., Shimizu, T., and Kato, S: Tissue-specific response of the human platelet-activating factor receptor gene to retinoic acid and thyroid hormone by ﾊalternative promoter usage. Proc. Natl. Acad. Sci. U.S.A. 93, 774-779 (1996)
5. Mori, M., Aihara, M., Kume, K., Hamanoue, M., Kohsaka, S., and Shimizu, T: Predominant expression of platelet-activating factor receptor in the rat brain microglia. J. Neurosci. 16, 3590-3600 (1996)
6. Yokomizo, T., Izumi, T., Chang, K.K., Takuwa, Y., and Shimizu, T.: A G-protein coupled receptor for leukotriene B4 that mediates chemotaxis. Nature 387, 620-624 (1997)
7. Uozumi, N., Kume, K., Nagase, T., Nakatani, N., Ishii, S., Tashiro, F., Komagata, Y., Maki, K., Ikuta, K., Ouchi, Y., Miyazaki, J., and Shimizu, T. A major role for cytosolic phospholipase A2 in allergic responses and parturition. Nature 390, 618-622 (1997)
8. Ishii, S., Kuwaki, T., Nagase, T., Maki, K., Tashiro, F., Sunaga, S., Cao, W-H., Fukuchi, Y., Ikuta, K., Miyazaki, J., Kumada, M. and Shimizu, T. Impaired anaphylactic responses with intact sensitivity to endotoxin in mice lacking a platelet-activating factor receptor. J. Exp. Med. 187, 1779-1788 (1998)
9. Nagase, T., Ishii, S., Kume, K., Uozumi, N., Izumi, T., Ouchi, Y., and Shimizu, T. Platelet-activating factor mediated acid-induced lung injury in genetically-engineered mice. J. Clin. Invest. 104, 1071-1076 (1999)
10. Noiri, E., Yokomizo, T., Nakao, A., Izumi, T., Fujita, T., Kimura, S., and Shimizu, T. A novel in vivo approach showing the chemotactic activity of leukotriene B4 in acute ischemic-reperfusion injury. Proc. Natl. Acad. Sci. USA 97, 823-828, (2000).
11. Nagase, T., Uozumi, N., Ishii, S., Kume, K., Izumi, T., Ouchi, Y., and Shimizu, T. Acute lung injury by sepsis and acid aspiration: a key role of cytosolic phospholipase A2. Nature Immunol. 1, 42-46 （2000）
12. Kato, K., Yokomizo, T., Izumi, T., and Shimizu, T. Cell-specific transcriptional regulation of human leukotriene B4 receptor gene. J. Exp. Med. 192: 413-420 (2000).
13. Yokomizo, T., Kato, K., Terawaki, K., Izumi, T., and Shimizu, T. A second leukotriene B4 receptor, BLT2: a new therapeutic target in inflammation and immunological disorders. J. Exp. Med. 192: 421-432(2000).
14. Takaku, K, Sonoshita, M., Sasaki, N., Uozumi, N., Doi, Y., Shimizu, T., and Taketo, M.M. Suppression of intestinal polyposis in Apc-716 knockout mice by an additional mutation in the cytosolic phospholipase A2 gene. J. Biol. Chem. 275, 34013-34016 (2000) (Accelerated publication)
15. Yokomizo, T., Kato, K., Hagiya, H., Izumi, T., and Shimizu, T. (2001) Hydroxyeicosanoids bind to and activate the low-affinity leukotriene B4 receptor, BLT2. J. Biol. Chem. 276: 12454-12459.
16. Nagase, T., Uozumi, N., Ishii, S., Kita, Y., Yamamoto, H., Ohga, E., Ouchi, Y. and Shimizu, T. (2002) A pivotal role of cytosolic phospholipase A2 in bleomycin-induced pulmonary fibrosis. Nature Med. 8, 480-484
17. Wong, DA, Kita, K., Uozumi, N., and Shimizu, T. (2002) Discrete role for cytosolic phospholipase A2a in platelets:studies using single and double knockout mutant mice of cytosolic and group IIA secretory phospholipase A2. J. Exp. Med. 196, 349-353.
18. Miyaura,C. Inada, M, Matsumoto, C., Ohshiba, T. Uozumi, N., Shimizu, T., and Ito, A (2003). An essential role of cytosolic phospholipase A2a in prostaglandin E2-mediated bone resorption associated with inflammation. J. Exp. Med. 197, 1303-1310
19. Hegen, M.,Sun, L, Uozumi, N., Kume, K., Goad, M. E., Nickerson-Nutter, C. L., Shimizu, T., and Clark, J. D. (2003) Cytosolic phospholipase !sa-deficient mice are resistant to collagen-induced arthritis. J. Exp. Med. 197, 1297-1302.
20. Hikiji, H., Ishii, S., Shindou, H., Takato, T., and Shimizu, T. (2004) Absence of platelet-activating factor receptor protects mice from osteoporosis following ovariectomy. J. Clin. Invest. 114, 85-93
21. Marusic, S., Leach, M.W., Pelker, J.W., Azoitei, M.L., Uozumi, N., Cui, J., DeClercq, C.M., Shen, M.W.H., Miyashiro, J.S., Carito, B.A., Thakker, P., Simmons, D.L., Leonard, J.P., Shimizu, T., and Clark, J.D. (2005) Cytosolic phospholipase A2alpha-deficient mice are resistant to experimental autoimmune encephalomyelitis. J. Exp. Med. 202, 841-851
22. Kihara, Y., Ishii, S., Kita, Y., Toda, A., Shimada, A., and Shimizu, T. (2005) Dual phase regulation of experimental allergic encephalomyelitis by platelet-activating factor. J. Exp. Med. 202, 853-863
23. Yoshikawa, K., Kita, Y., Kishimoto, K., and Shimizu, T. (2006) Profiling of eicosanoid production in the rat hippocampus during kainate-induced seizure: Dual-phase regulation and differential involvement of cox-1 and cox-2. J. Clin. Invest. 281, 14663-14669
24. Nakanishi, H., Shindou, H., Hishikawa, D., Harayama, T., Ogasawara, R., Suwabe, A., Taguchi, R., and Shimizu, T. (2006) Cloning and characterization of mouse lung-type acyl-coa:lysophosphatidylcholine acyltransferase 1 (LPCAT1): Expression in alveolar type II cells, and possible involvement in surfactant production. J. Biol. Chem. 281, 20140-20147
25. Yanagida, K., Ishii, S., Hamano, F., Noguchi, K., and Shimizu, T. (2007) LPA4/p2y9/GPR23 mediates Rho-dependent morphological changes in a rat neuronal cell line. J. Biol. Chem. 282, 5814-5824
26. Okuno, T., Iizuka, Y., Okazaki, H., Yokomizo, T., Taguchi, R., and Shimizu, T. (2008) 12(S)-Hydroxyheptadeca-5Z, 8E, 10E-trienoic acid is a natural ligand for leukotriene B4 receptor 2. J. Exp. Med. 205, 759-766
27. Tsujimura, Y., Obata, K., Mukai, K., Shindou, H., Yoshida, M., Nishikado, H., Kawano, Y., Minegishi, Y., Shimizu, T., and Karasuyama, H. (2008) Basophils play a pivotal role in IgG-, but not IgE-mediated systemic anaphylaxis in contrast to mast cells. Immunity 28, 581-589
28. Harayama, T*., Shindou, H*. (*, equal contribution), Ogasawara, R., Suwabe, A, and Shimizu, T. (2008) Identification of a novel non-inflammatory biosynthetic pathway of platelet-activating factor. J. Biol. Chem 283, 11097-11106
29. Hishikawa, D*., Shindou, H*. (*, equal contribution), Kobayashi, S., Nakanishi, H., Taguchi, R., and Shimizu, T. (2008) Discovery of a lysophospholipid acyltransferase family essential for membrane asymmetry and diversity. Proc. Natl. Acad. Sci. USA 105, 2830-2835
30. Shindou H. and Shimizu T. (2009) Acyl-CoA:lysophospholipid acyltransferases. J. Biol. Chem 284, 1-5
31. Kihara, Y., Matsushita, T., Kita, Y., Uematsu, S., Akira, S., Kira, J.-i., Ishii, S., and Shimizu, T. (2009) Targeted lipidomics reveals mPGES-1-PGE2 as a therapeutic target for multiple sclerosis. Proc. Natl. Acad. Sci. USA 106, 21807-21812
32. Hikiji, H., Ishii, S., Yokomizo, T., Takato, T., and Shimizu, T. (2009) A distinctive role of the leukotriene B4 receptor BLT1 in osteoclastic activity during bone loss. Proc. Natl. Acad. Sci. USA 106, 21294-21299
33. Shimizu, T. (2009) Lipid mediators in health and diseases. Ann. Rev. Pharmacol. Toxicol. 49, 123-150