Major Publications

2008, 2007, 2006, 2005, 2004, 2003, 2002, 2001, 2000, 1999, 1998, 1997, 1996, 1995, 1994, 1993, 1992, 1991, Reviews, Reviews in Japanese, Complete works of Professor Shimizu

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Complete works of Professor Takao Shimizu

Original Articles

  1. Kitamura, S., Ishihara, Y., Sasaki, K., Shimizu, T., and Kosaka, K.: Effect of mixture of prostaglandin E1 and F2a on the guinea pig trachea. Advances Prostaglandin, Thromboxane Res. 2: 962 (1976)
  2. Kitamura, S., Ishihara, Y., Shimizu, T., and Kosaka, K.: Prostaglandin inactivation in normal and sensitized guinea pig lung and its inhibition by indomethacin. Jap. J. Med. 15: 12-17 (1976)
  3. Hayaishi, O., Hirata, F., Ohnishi, T., Yoshida, R., and Shimizu, T.: A new assay procedure for indoleamine 2,3-dioxygenase. Advances Exp. Med. Biol. 74: 335-342 (1976)
  4. Hirata, F., Shimizu, T., Yoshida, R., Ohnishi, T., Fujiwara, M., and Hayaishi, O.: Copper content of indoleamine 2,3-dioxygenase. Advances Exp. Med. Biol. 74: 354-357 (1976) 　
  5. Kitamura, S., Ishihara, Y., Sasaki, K., Shimizu, T., and Harasawa, M.: Effect of dihydroergotoxine on activities of b-receptor stimulators. Drug Res. 27: 1959-1961 (1977)
  6. Shimizu, T., Nomiyama, S., Hirata, F., and Hayaishi, O.: Indoleamine 2,3-dioxygenase. Purification and some properties. J. Biol. Chem. 253: 4700-4706 (1978)
  7. Kitamura, S., Shimizu, T., Ishihara, Y.: Effects of 5-hydroxykynurenamine, a metabolite of 5-hydroxytryptamine, on guinea pig isolated trachea. J. Pharm. Pharmacol. 31: 45-46 (1979)
  8. Shimizu, T., Yamamoto, S., and Hayaishi, O.: Purification and properties of prostaglandin D synthetase from rat brain. J. Biol. Chem. 254: 5222-5228 (1979)
  9. Shimizu, T., Mizuno, N., Amano, T., and Hayaishi, O.: Prostaglandin D2, a neuromodulator. Proc. Natl. Acad. Sci. U. S. A. 76: 6231-6234 (1979)
  10. Yamamoto, S., Ohki, S., Ogino, N., Shimizu, T., Yoshimoto, T., Watanabe, K., and Hayaishi, O.: Enzymes involved in the formation and further transformations of prostaglandin endoperoxides. Advances in Prostaglandin, Thromboxane and Leukotriene Res. 6: 27-34 11.
  11. Watanabe, K., Shimizu, T., Iguchi, S., Wakatsuka, H., Hayashi, M., and Hayaishi, O.: An NADP-linked prostaglandin D2 dehydrogenase in swine brain. J. Biol. Chem. 255: 1779-1782 (1980)
  12. Shimizu, T., Kondo, K., and Hayaishi, O.: Role of prostaglandin endoperoxides in the serum thiobarbituric acid reaction. Arch. Biochem. Biophys. 206: 271-276 (1981)
  13. Shimizu, T., Watanabe, K., and Hayaishi, O.: Metabolism and functions of prostaglandin D2 in the brain. Neurochem. Res. 6: 113-117 (1981)
  14. Kondo, K., Shimizu, T., and Hayaishi, O.: Effects of prostaglandin D2 on membrane potential in neuroblastoma X glioma hybrid cells as determined with a cyanine dye. Biochem. Biophys. Res. Commun. 98: 648-655 (1981)
  15. Watanabe, K., Shimizu, T., and Hayaishi, O.: Enzymatic conversion of prostaglandin D2 to F2a in the rat lung. Biochem. Int. 2: 603-610 (1981)
  16. Watanabe, T., Shimizu, T., Narumiya, S., and Hayaishi, O.: NADP-linked prostaglandin D2 dehydrogenase in human blood platelets. Arch. Biochem. Biophys. 216: 372-379 (1982)
  17. Ueno, R., Shimizu, T., Kondo, K., and Hayaishi, O.: Activation mechanism of prostaglandin endoperoxide synthetase by hemoproteins. J. Biol. Chem. 257: 5584-5588 (1982)
  18. Kinoshita, F., Nakai, Y., Katakami, H., Imura, H., Shimizu, T., and Hayaishi, O.: Suppressive effect of prostaglandin D2 on pulsatile luteinizing hormone release in conscious rats. Endocrinology 110: 2207-2209 (1982)
  19. Shimizu, T., Yamashita, A., and Hayaishi, O.: Specific binding of prostaglandin D2 to rat brain synaptic membrane. Occurrence, properties and distribution. J. Biol. Chem. 257: 13570-13575 (1982)
  20. Tokumoto, H., Watanabe, K., Fukushima, D., Shimizu, T., and Hayaishi, O.: An NADP-linked prostaglandin 15-hydroxyprostaglandin dehydrogenase specific for prostaglandin D2 from swine brain. J. Biol. Chem. 257: 13576-13580 (1982)
  21. Watanabe, T., Narumiya, S., Shimizu, T., and Hayaishi, O.: Characterization of the biosynthetic pathway of prostaglandin D2 in human platelet- rich plasma. J. Biol. Chem. 257: 14847-14853 (1982)
  22. Radmark, O., Shimizu, T., Fitzpatrick, F., and Samuelsson, B.: Hemoprotein catalysis of leukotriene formation. Biochim. Biophys. Acta 792: 324-329 (1984)
  23. Shimizu, T., Radmark, O., and Samuelsson, B.: Enzyme with dual lipoxygenase activities catalyzes leukotriene A4 synthesis from arachidonic acid. Proc. Natl. Acad. Sci. U. S. A. 81: 689-693 (1984)
  24. Radmark, O., Shimizu, T., Jornvall, H., and Samuelsson, B.: Leukotriene A4 hydrolase in Human Leukocytes: Purification and properties. J. Biol. Chem. 259: 12339-12345 (1984)
  25. Watanabe, K., Yoshida, R., Shimizu, T., and Hayaishi, O.: Enzymatic formation of prostaglandin F2a from Prostaglandin H2 and D2: Purification and properties of prostaglandin F synthetase. J. Biol. Chem. 260: 7035-7041 (1985)
  26. Radmark, O., Shimizu, T., Jornvall, H., and Samuelsson, B.: Leukotriene A4: Mechanism of formation and enzymatic hydrolysis. Advances Pharmacol. Therap. 25-28 (1985)
  27. Shimizu, T., Radmark, O., and Samuelsson, B.: The biosynthesis of leukotriene A4 from 5-hydroperoxyeicosatetraenoic acid: Possible involvement of 8-lipoxygenase reaction. Advances Prostaglandin Thromboxane Leukotriene Res. 15: 177-180 (1985)
  28. Watanabe, K., Yoshida, R., Shimizu, T., and Hayaishi, O.: Biosynthesis of PGF2a from PGH2 and PGD2 by an apparently homogeneous enzyme. Advances Prostaglandin Thromboxane Leukotriene Res. 15: 151-153 (1985)
  29. Rouzer, C., Shimizu, T., and Samuelsson, B.: On the nature of the 5-lipoxygenase reaction in human leukocytes: Characterization of a membrane-associated stimulatory factor. Proc. Natl. Acad. Sci. U. S. A. 82: 7505-7509 (1985)
  30. Izumi, T., Shimizu, T., Kasama, T., Seyama Y., Sumimoto, H., Takeshige, K., Minakami, S., Wetterholm, A., and Radmark, O.: A simultaneous quantitation of leukotriene B4 and its w-oxidized products by gas chromatography-mass spectrometry. Biochem. Biophys. Res. Commun. 134: 512-518 (1986)
  31. Izumi, T., Shimizu, T., Seyama, Y., Ohishi, N., and Takaku, F.: Tissue distribution of leukotriene A4 hydrolase activity in guinea pig. Biochem. Biophys. Res. Commun. 135: 139-145 (1986)
  32. Shimizu, T., Izumi, T., Seyama, Y., Tadokoro, K., Radmark, O., and Samuelsson, B.: Characterization of leukotriene A4 synthase from murine mast cells. Evidence of its identity to arachidonate 5-lipoxygenase. Proc. Natl. Acad. Sci. U. S. A. 83: 4175-4179 (1986)
  33. Rouzer, C., Matsumoto, T., Shimizu, T., and Samuelsson, B: Purification and properties of 5-lipoxygenase in human leukocytes. Advances. Prostaglandin, Thromboxane and Leukotriene Res. 16: 3-16 (1986)
  34. Shimizu, T., Takusagawa, Y., Izumi, T., Ohishi, N., and Seyama, Y: Enzymatic synthesis of leukotriene B4 in the guinea pig brain. J. Neurochem. 48: 1541-1546 (1987)
  35. Kume, K., Shimizu, T., and Seyama, Y: Characterization of sn-Glycerol 3-phosphate acyltransferase from guinea pig Harderian gland. J. Biochem. 101: 653-660 (1987)
  36. Kitamura, S., Shimizu, T., Izumi, T., and Seyama, Y: Synthesis of 11,12-leukotriene A4 (11S, 12S-oxido-5-cis-8,10trans-14- ciseicosatetraenoic acid, a novel leukotriene of 12-lipoxygenase pathway. FEBS Lett. 213: 169-173 (1987)
  37. Shimizu, T., Izumi, T., Ohishi, N., Seyama, Y, and Kitamura, S: Biosynthesis and further transformations of leukotriene A4. Advances Prostaglandin Thromboxane Leukotriene Res. 17: 64-68 (1987)
  38. Ohishi, N., Izumi, T., Kitamura, S., Minami, M., Seyama, Y., Ohkawa, S., Terao, S., Yotsumoto, H., Takaku, F., and Shimizu, T: Leukotriene A4 hydrolase in human lung: inactivation of the enzyme with leukotriene A4 isomers. J. Biol. Chem. 262, 10200-10205 (1987)
  39. Minami, M., Ohno, S., Kawasaki, H., Radmark, O., Samuelsson, B., Shimizu, T., Seyama, Y., and Suzuki, K: Molecular cloning of a cDNA coding for human leukotriene A4 hydrolase; complete primary structure of an enzyme involved in eicosanoid synthesis. J. Biol. Chem. 262, 13873-13878 (1987)
  40. Funk, C., Radmark, O., Fu, J-Y., Matsumoto, T., Jornvall, H., Shimizu, T., and Samuelsson, B: Leukotriene A4 hydrolase, molecular cloning and amino acid sequence. Proc. Natl. Acad. Sci. U. S. A. 84, 6677-6681 (1987)
  41. Tsuchida, S., Izumi, T., Shimizu, T., Ishikawa, T., Hatayama, I., Satoh, K., and Sato, K: Purification of a new acidic glutathione S-transferase, GST-Yn1Yn1, with a high leukotriene C4 synthase activity from rat brain. Eur. J. Biochem. 170, 159-164 (1987)
  42. Minami, M., Minami, Y., Emori, Y., Kawasaki, H., Ohno, S., Suzuki, K., Ohishi, N., Shimizu, T., and Seyama, Y: Expression of human leukotriene A4 hydrolase cDNA in Escherichia coli. FEBS Lett. 229, 279-282 (1988)
  43. Byun, D-S., Kasama, T., Shimizu, T., Yorifuji, H., and Seyama, Y: Effect of cholestanol feeding on sterol concentrations in the serum, liver and cerebellum of mice. J. Biochem. 103, 375-379 (1988)
  44. Watanabe, T., Asano, T., Shimizu, T., Seyama, Y., and Takakura, K: Participation of lipoxygenase products from arachidonic acid in the pathogeneses of cerebral vasospasm. J. Neurochem. 50, 1145-1150 (1988)
  45. Izumi, T., Honda, Z., Ohishi, N., Kitamura, S., Tsuchida, S., Sato, K., Shimizu, T., and Seyama, Y: Solubilization and partial purification of leukotriene C4 synthase from guinea pig lung: a microsomal enzyme with high specificity towards 5,6-epoxide leukotriene A4. Biochim. Biophys. Acta 959: 305-315 (1988)
  46. Shimizu, T., Watanabe, T., Asano, T., Seyama, Y., and Takakura, K: Activation of the arachidonate 5-lipoxygenase pathway in the canine basilar artery after the subarachnoidal hemorrhage. J. Neurochem. 51, 1126-1131 (1988)
  47. Kitamura, S., Shimizu, T., Miki, I., Izumi, T., and Seyama, Y: Synthesis and structural identification of four dihydroxy acids and 11,12- leukotriene C4 derived from 11,12-leukotriene A4. Eur. J. Biochem. 176 725-731 (1988)
  48. Izumi, T., Honda, Z., Ohishi, N., Kitamura, S., Seyama, Y., and Shimizu, T: Partial purification and characterization of leukotriene C4 synthase from guinea pig lung. Advances Prostaglandin, Thromboxane and Leukotriene Res. 19, 90-93 (1989)
  49. Minami, M., Minami, Y., Ohno, S., Suzuki, K., Ohishi, N., Shimizu, T., and Seyama, Y: Molecular cloning and expression of human leukotriene A4 hydrolase cDNA. Advances Prostaglandin, Thromboxane and Leukotriene Res. 19, 478-483 (1989)
  50. Miki, I., Kitamura, S., Shimizu, T., and Seyama, Y: 11,12-Leukotriene A4: Synthesis and metabolism. Advances Prostaglandin, Thromboxane and Leukotriene Res. 19, 98-101 (1989)
  51. Bito, H., Ohishi, N., Miki, I., Minami, M., Tanabe, T., Shimizu, T., and Seyama, Y: Purification and properties of leukotriene A4 hydrolase from the guinea pig lung. J. Biochem. 105 , 261-264 (1989)
  52. Kurachi, Y., Ito, H., Sugimoto, T., Shimizu, T., Miki, I., and Ui, M.: Arachidonic acid metabolites as intracellular modulators of G protein-gated cardiac K channel. Nature 337, 555-557 (1989)
  53. Miki, I., Shimizu, T., Seyama, Y., Kitamura, S., Yamaguchi, K., Sano, H., Ueno, H., Hiratsuka, A., and Watabe, T.: Enzymic conversion of 11,12-leukotriene A4 to 11,12-dihydroxy-5,14-cis-7,9- trans-eicosatetraenoic acid: Purification of an epoxide hydrolase from the guinea pig liver cytosol. J. Biol. Chem. 264, 5799-5805 (1989)
  54. Takeuchi, K., Shimizu, T., Ohishi, N., Seyama, Y., Takaku, F., and Yotsumoto, S: Purification of human lung angiotensin converting enzyme by high performance liquid chromatography: Properties and N-terminal amino acid sequence. J. Biochem. 106, 442-445 (1989)
  55. Kurachi, Y., Ito, H., Sugimoto, T., Shimizu, T., Miki, I., and Ui, M.: a-Adrenergic activation of the muscarinic K+ channel is mediated by arachidonic acid metabolites. Pflugers Arch. 414, 102-104 (1989)
  56. Sugiyama, Y., Izumi, T., Ohishi, N., Yotsumoto, H., Shimizu, T., Kitamura, S., and Takaku, F: Effects of smoking on the synthesis of leukotriene B4 by rat alveolar macrophages. Respiration 56: 198-203 (1989)
  57. Kuo, T-M., Taketani, Y., Shimizu, T., and Mizuno, M: A possible mechanism of infertility in endometriosis. a role of Interleukin-1 in peritoneal fluid. Assisted Reproductive Technology Andrology 1, 24-31 (1990)
  58. Miki, I., Seyama, Y., Ui, M., Sato, F., and Shimizu, T: Characterization of leukotriene B4 receptor in porcine spleen and leukocytes. Biochem. Biophys. Res. Commun. 166 342-348 (1990)
  59. Ohishi, N., Minami, M., Kobayashi, J., Seyama, Y., Hata, J., Yotsumoto, H., Takaku, F., and Shimizu, T: Immunological quantitation and immunohistochemical localization of leukotriene A4 hydrolase. J. Biol. Chem. 265 7520-7525 (1990)
  60. Nagase, T., Fukuchi, Y., Shimizu, T., Matsuse, T., and Orimo, H: Reduction of 15-hydroxyeicosatetraenoic acid (15-HETE) in tracheal fluid with high frequency oscillatory ventilation. Prostaglandin, Leukotrienes and Essential Fatty Acids. 40 177-180 (1990)
  61. Watanabe, T., Shimizu, T., Miki, I., Sakanaka, C., Honda, Z., Seyama, Y., Teramoto, T., Matsushima, T., Ui, M., and Kurokawa, K: Characterization of the guinea pig lung membrane leukotriene D4 receptor solubilized in an active form: Association and dissociation with an islet-activating protein -sensitive GTP binding protein. J. Biol. Chem. 265 21237-21241 (1990)
  62. Nagase, T., Fukuchi, Y., Shimizu, T., and Orimo, H: Endothelin-1 stimulates arachidonate 15-lipoxygenase activity and oxygen radical formation in the rat distal lung. Biochem. Biophys. Res. Commun. 168 485-489 (1990)
  63. Toh, H., Minami, M., and Shimizu, T: Molecular evolution and zinc ion binding motif of leukotriene A4 hydrolase. Biochem. Biophys. Res. Commun. 171 216-219 (1990)
  64. Ishihara, O., Kinoshita, K., Satoh, K., Mizuno, M., and Shimizu, T: An inhibitor of prostaglandin biosynthesis from human decidua: partial purification and properties. Prostaglandins Leukotrienes and Essential Fatty Acids 40 223-226 (1990)
  65. Minami, M., Ohishi, N., Mutoh, H., Izumi, T., Bito, H., Wada, H., Seyama, Y., Toh, H., and Shimizu, T.: Leukotriene A4 hydrolase is a zinc-containing aminopeptidase. Biochem. Biophys. Res. Commun. 173 620-626 (1990)
  66. Shimizu, T., Miki, I., Ohishi, N., and Seyama, Y: Biosynthesis and receptor of leukotriene B4. Advances Prostaglandin, Thromboxane and Leukotriene Res. 21: 387-394 (1990)
  67. Takano, T., Honda, Z., Watanabe, T., Uchida, S., Shimizu, T., and Kurokawa, K. (1991) Demonstration of platelet activating factor receptor in guinea pig kidney. Biochem. Biophys. Res. Commun. 177, 54-60
  68. Watanabe, T., Shimizu, T., Nakao, A., Taniguchi, S., Arata, Y., Teramoto, T., Seyama, Y., Ui, M., and Kurokawa, K. (1991) Characterization of partially purified prostaglandin E2 receptor from the canine renal medulla: evidence for physical association of the receptor protein with the inhibitory guanine nucleotide-binding protein. Biochim. Biophys. Acta 1074, 398-405
  69. Watanabe, T., Yatomi, Y., Sunaga, S., Miki, I., Ishii, A., Nakao, A., Higashihara, M., Seyama, Y., Ogura, M., Saito, H., Kurokawa, K., and Shimizu, T. (1991) Characterization of prostaglandin and thromboxane receptors expressed on a megakaryoblastic leukemia cell line, MEG-01s. Blood 78, 2328-2336
  70. Yamashita, T., Shimizu, T., and Ogata, E. (1991) Activin A/erythroid differentiation factor induces thromboxane A2 synthetic activity in murine erythroleukemia cells. J. Biol. Chem. 266, 3888-3892
  71. Nakamura, M., Honda, Z., Izumi, T., Sakanaka, C., Mutoh, H., Minami, M., Bito, H., Seyama, Y., Matsumoto, T., Noma, M., and Shimizu, T. (1991) Molecular cloning and expression of platelet-activating factor receptor from human leukocytes. J. Biol. Chem. 266, 20400-20405
  72. Honda, Z., Nakamura, M., Miki, I., Minami, M., Watanabe, T., Seyama, Y., Okado, H., Toh, H., Ito, K., Miyamoto, T., and Shimizu, T. (1991) Cloning by functional expression of platelet-activating factor receptor from guinea-pig lung. Nature 349, 342-346
  73. Mike, I., Ichikawa, Y., Shimizu, T., Honda, Z. I., Seyama, Y., and Ishii, A. (1991) The differences in 12-hydroxyeicosatetraenoic acid and thromboxane B2 release from guinea pig platelets. Prostaglandins 42, 431-440
  74. Sugimoto, T., Tsuchimochi, H., McGregor, C. G., Mutoh, H., Shimizu, T., and Kurachi, Y. (1992) Molecular cloning and characterization of the platelet-activating factor receptor gene expressed in the human heart. Biochem. Biophys. Res. Commun. 189, 617-624
  75. Jamil, K. M., Takano, T., Nakao, A., Honda, Z., Shimizu, T., Watanabe, T., and Kurokawa, K. (1992) Expression of platelet activating factor receptor in renal tubular cell line (LLC-PK1). Biochem. Biophys. Res. Commun. 187, 767-772
  76. Shimizu, T., Honda, Z., Nakamura, M., Bito, H., and Izumi, T. (1992) Platelet-activating factor receptor and signal transduction. Biochem. Pharmacol. 44, 1001-1008
  77. Sakanaka, C., Izumi, T., Nakamura, M., Honda, Z., Watanabe, T., Minami, M., Mutoh, H., Bito, H., Seyama, Y., Ui, M., and Shimizu, T. (1992) Three types of Gi alpha protein of the guinea-pig lung: cDNA cloning and analysis of their tissue distribution. Biochim. Biophys. Acta 1175, 61-66
  78. Nagata, K., Takakura, K., Asano, T., Seyama, Y., Hirota, H., Shigematsu, N., Shima, I., Kasama, T., and Shimizu, T. (1992) Identification of 7 alpha-hydroxy-3-oxo-4-cholestenoic acid in chronic subdural hematoma. Biochim. Biophys. Acta 1126, 229-236
  79. Nakamura, M., Honda, Z., Waga, I., Matsumoto, T., Noma, M., and Shimizu, T. (1992) Endotoxin transduces Ca2+ signaling via platelet-activating factor receptor. FEBS Lett. 314, 125-129
  80. Minami, M., Bito, H., Ohishi, N., Tsuge, H., Miyano, M., Mori, M., Wada, H., Mutoh, H., Shimada, S., Izumi, T., Abe, K., Shimizu, T. (1992) Leukotriene A4 hydrolase, a bifunctional enzyme. Distinction of leukotriene A4 hydrolase and aminopeptidase activities by site-directed mutagenesis at Glu-297. FEBS Lett. 309, 353-357
  81. Bito, H., Nakamura, M., Honda, Z., Izumi, T., Iwatsubo, T., Seyama, Y., Ogura, A., Kudo, Y., and Shimizu, T. (1992) Platelet-activating factor (PAF) receptor in rat brain: PAF mobilizes intracellular Ca2+ in hippocampal neurons. Neuron 9, 285-294
  82. Bito, H., Sakanaka, C., Takano, T., Kudo, Y., and Shimizu, T. (1993) Molecular cloning of a novel type of somatostatin receptor and platelet-activating factor receptor cDNAs from rat. Ann. N. Y. Acad. Sci. 707, 480-481
  83. Waga, I., Nakamura, M., Honda, Z., Ferby, I., Toyoshima, S., Ishiguro, S., and Shimizu, T. (1993) Two distinct signal transduction pathways for the activation of guinea-pig macrophages and neutrophils by endotoxin. Biochem. Biophys. Res. Commun. 197, 465-472
  84. Mori, M., Izumi, T., and Shimizu, T. (1993) Energy-dependent export of leukotriene B4 in Xenopus oocytes. Biochim. Biophys. Acta 1168, 23-29
  85. Mutoh, H., Bito, H., Minami, M., Nakamura, M., Honda, Z., Izumi, T., Nakata, R., Kurachi, Y., Terano, A., and Shimizu, T. (1993) Two different promoters direct expression of two distinct forms of mRNAs of human platelet-activating factor receptor. FEBS Lett. 322, 129-134
  86. Yokomizo, T., Izumi, T., Takahashi, T., Kasama, T., Kobayashi, Y., Sato, F., Taketani, Y., and Shimizu, T. (1993) Enzymatic inactivation of leukotriene B4 by a novel enzyme found in the porcine kidney. Purification and properties of leukotriene B4 12-hydroxydehydrogenase. J. Biol. Chem. 268, 18128-18135
  87. Bito, H., Kudo, Y., and Shimizu, T. (1993) Characterization of platelet-activating factor (PAF) receptor in the rat brain. J. Lipid Mediat. 6, 169-174
  88. Shirasaki, H., Nishikawa, M., Adcock, I. M., Mak, J. C., Sakamoto, T., Shimizu, T., and Barnes, P. J. (1994) Expression of platelet-activating factor receptor mRNA in human and guinea pig lung. Am. J. Respir. Cell Mol. Biol. 10, 533-537
  89. Bigby, T. D., Lee, D. M., Minami, M., Ohishi, N., Shimizu, T., and Baker, J. R. (1994) Characterization of human airway epithelial cell leukotriene A4 hydrolase. Am. J. Respir. Cell Mol. Biol. 11, 615-624
  90. Mori, M., Bito, H., Sakanaka, C., Honda, Z., Kume, K., Izumi, T., and Shimizu, T. (1994) Activation of mitogen-activated protein kinase and arachidonate release via two G protein-coupled receptors expressed in the rat hippocampus. Ann. N. Y. Acad. Sci. 744, 107-125
  91. Sakanaka, C., Ferby, I., Waga, I., Bito, H., and Shimizu, T. (1994) On the mechanism of cytosolic phospholipase A2 activation in CHO cells carrying somatostatin receptor: wortmannin-sensitive pathway to activate mitogen-activated protein kinase. Biochem. Biophys. Res. Commun. 205, 18-23
  92. Mutoh, H., Kume, K., Sato, S., Kato, S., and Shimizu, T. (1994) Positive and negative regulations of human platelet-activating factor receptor transcript 2 (tissue-type) by estrogen and TGF-beta 1. Biochem. Biophys. Res. Commun. 205, 1130-1136
  93. Mutoh, H., Ishii, S., Izumi, T., Kato, S., and Shimizu, T. (1994) Platelet-activating factor (PAF) positively auto-regulates the expression of human PAF receptor transcript 1 (leukocyte-type) through NF-kappa B. Biochem. Biophys. Res. Commun. 205, 1137-1142
  94. Kobayashi, Y., Shimazaki, T., Kawajiri, K., Shimizu, T., Seyama, Y., and Sato, F. (1994) Important contribution of the methylene part of LTB4 toward binding affinity to the LTB4 receptors and rise in intracellular-free calcium concentration. Biochim. Biophys. Acta 1215, 280-284
  95. Bito, H., Honda, Z., Nakamura, M., and Shimizu, T. (1994) Cloning, expression and tissue distribution of rat platelet-activating-factor-receptor cDNA. Eur. J. Biochem. 221, 211-218
  96. Liu, B., Nakashima, S., Kanoh, H., Takano, T., Shimizu, T., and Nozawa, Y. (1994) Activation of phospholipase D in Chinese hamster ovary cells expressing platelet-activating factor receptor. J. Biochem. (Tokyo) 116, 882-891
  97. Takano, T., Honda, Z., Sakanaka, C., Izumi, T., Kameyama, K., Haga, K., Haga, T., Kurokawa, K., and Shimizu, T. (1994) Role of cytoplasmic tail phosphorylation sites of platelet-activating factor receptor in agonist-induced desensitization. J. Biol. Chem. 269, 22453-22458
  98. Honda, Z., Takano, T., Gotoh, Y., Nishida, E., Ito, K., and Shimizu, T. (1994) Transfected platelet-activating factor receptor activates mitogen-activated protein (MAP) kinase and MAP kinase kinase in Chinese hamster ovary cells. J. Biol. Chem. 269, 2307-2315
  99. Ferby, I. M., Waga, I., Sakanaka, C., Kume, K., and Shimizu, T. (1994) Wortmannin inhibits mitogen-activated protein kinase activation induced by platelet-activating factor in guinea pig neutrophils. J. Biol. Chem. 269, 30485-30488
  100. Bito, H., Mori, M., Sakanaka, C., Takano, T., Honda, Z., Gotoh, Y., Nishida, E., and Shimizu, T. (1994) Functional coupling of SSTR4, a major hippocampal somatostatin receptor, to adenylate cyclase inhibition, arachidonate release and activation of the mitogen-activated protein kinase cascade. J. Biol. Chem. 269, 12722-12730
  101. Kajihara, A., Komooka, H., Kamiya, K., Yoneda, T., Yoneda, S., Nakamura, M., Shimizu, T., and Umeyama, H. (1994) Three-dimensional model of the human PAF receptor. J. Lipid Mediat. Cell Signal 9, 185-196
  102. Tsuge, H., Ago, H., Aoki, M., Furuno, M., Noma, M., Miyano, M., Minami, M., Izumi, T., and Shimizu, T. (1994) Crystallization and preliminary X-ray crystallographic studies of recombinant human leukotriene A4 hydrolase complexed with bestatin. J. Mol. Biol. 238, 854-856
  103. Liu, B., Nakashima, S., Takano, T., Shimizu, T., and Nozawa, Y. (1995) Implication of protein kinase C alpha in PAF-stimulated phospholipase D activation in Chinese hamster ovary (CHO) cells expressing PAF receptor. Biochem. Biophys. Res. Commun. 214, 418-423
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  178. Yamamoto, T., Yokomizo, T., Nakao, A., Izumi, T., and Shimizu, T. (2001) Immunohistochemical localization of guinea-pig leukotriene B4 12-hydroxydehydrogenase/15-ketoprostaglandin 13-reductase. Eur. J. Biochem. 268, 6105-6113
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  180. Wu, C., Stojanov, T., Chami, O., Ishii, S., Shimizu, T., Li, A., O'Neill, C., and Shimuzu, T. (2001) Evidence for the autocrine induction of capacitation of mammalian spermatozoa. J. Biol. Chem. 276, 26962-26968
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  182. Kim, Y. J., Noguchi, S., Hayashi, Y. K., Tsukahara, T., Shimizu, T., and Arahata, K. (2001) The product of an oculopharyngeal muscular dystrophy gene, poly(A)-binding protein 2, interacts with SKIP and stimulates muscle-specific gene expression. Hum. Mol. Genet. 10, 1129-1139
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  185. Banno, Y., Wang, S., Ito, Y., Izumi, T., Nakashima, S., Shimizu, T., and Nozawa, Y. (2001) Involvement of ERK and p38 MAP kinase in oxidative stress-induced phospholipase D activation in PC12 cells. Neuroreport 12, 2271-2275
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  203. Usui, H., Taniguchi, M., Yokomizo, T., and Shimizu, T. (2003) Interaction of plexin A1 and plexin B1 at the cytoplamic domain. Biochem. Biophys. Res. Commun. 24,927-31
  204. Nagase T., Uozumi N., Aoki-Nagase T., Terawaki K., Ishii S., Tomita T., Yamamoto H., Hashizume K., Ouchi Y., Shimizu T. (2003) A potent inhibitor of cytosolic phospholipase A2, arachidonyl trifluoromethyl ketone, attenuates LPS-induced lung injury in mice. Am J Physiol. Lung Cell Mol. Physiol. 284, L720-L726
  205. Asai, K, Hirabayashi, T, Houjou, T, Uozumi, N., Taguchi, R., and Shimizu, T. (2003) Human Group IVC phospholipase A2 (cPLA2): roles in the membrane remodeling and activation induced by oxidative stress. J. Biol. Chem. 278,8909-8914
  206. Miyaura, C., Inada, M., Matsumoto, C., Ohshiba, C., Uozumi, N., Shimizu, T., and Ito, A. (2003) An Essential Role of Cytosolic Phospholipase A2a in Prostaglandin E2-mediated Bone Resorption Associated with Inflammation J. Exp. Med. 197, 1303-1310
  207. Hegen, M., Sun L., Uozumi N., Kume K., Goad, E.M., Nickerson-Nutter L.C., Shimizu T., and Clark D.J. (2003) Cytosolic Phospholipase A2a deficient Mice Are Resistant to Collagen-induced Arthritis J. Exp. Med. 197, 1297-1302
  208. Yamauchi, T., Kamon, J., Ito, Y., Tsuchida, A., Yokomizo, T., Kita, S., Sugiyama, T., Miyagishi, M., Hara, K., Tsunoda, M., Murakami, K., Ohteki T., Uchida, S., Takenawa, S., Waki H., Tsuno, N.H., Shibata, Y., Terauchi, Y., Froguel, P., Tobe, K., Koyasu, S., Taira, K., Kitamura, T., Shimizu, T., Nagai, R., and Kadowaki, T. (2003) Cloning of adiponectin receptors that mediate antidiabetic metabolic effects. Nature 423, 762-768
  209. Noguchi, K., Ishii, S., and Shimizu, T. (2003) Identification of p2y9/GPR23 as a Novel G Protein-Coupled Receptor for Lysophosphatidic Acid, Structurally Distant from the Edg Family J. Biol. Chem. 278, 25600-25606
  210. Tokuoka, S. M., Ishii, S., Kawamura, N., Satoh, M., Shimada, A., Sasaki, S., Hirotsune, S., Wynshaw-Boris, A., and Shimizu, T. (2003) Involvement of Platelet-Activating Factor and LIS1 in Neuronal Migration. Eur. J. Neurosci. 18, 563-570
  211. Masuda, K., Itoh, H., Sakihama, T., Akiyama, C., Takahashi, K., Fukuda, R. Yokomizo, T., Shimizu, T., Kodama, T., and Hamakubo, T. (2003) A combinatorial G protein-coupled receptor reconstitution system on budded baculovirus: Evidence for Gai and Gao coupling to a human leukotriene B4 receptor. J. Biol. Chem. 278, 24552-24562
  212. Omura, M., Sekine, H., Shimizu, T., Kataoka, H, and Touhara, K. (2003) In situ Ca imaging of odor responses in a coronal olfactory epithelium slice. Neuroreport 14, 1123-1127
  213. Talvani, A., Santana, G., Barcelos, L. S., Ishii, S., Shimizu, T., Romanha, J., Silva, J. S., Soares, M. B. P. and Teixeira, M. M. (2003) Experimental Trypanosoma cruzi infection in platelet-activating factor -deficient mice. Microb. Infect. 5, 789-796
  214. Souza, D. G., Pinho, V., Soares, A. C. Shimizu, T., Ishii, S., and Teixeira, M. M. (2003) Role of PAF receptors during intestinal ischemia and reperfusion injury. A comparative study between PAF receptor-deficient mice and PAF receptor antagonist treatment. Brit. J. Pharmacol. 139, 733-740
  215. Weijer, S., Leemans, J. C., Florquin, S., Shimizu, T., Ishii, S., and van der Poll, T. (2003) Host response of platelet-activating factor receptor-deficient mice during pulmonary tuberculosis. Immunology, 109, 552-556
  216. Okuno, T., Ago, H., Terawaki., K, Miyano, M., Shimizu, T. and Yokomizo T. (2003) Helix 8 of the leukotriene B4 receptor is required for the conformational change to the low-affinity state after G-protein activation. J. Biol. Chem. 278, 41500-41509
  217. Obinata, H., Yokomizo, T., Shimizu, T. and Izumi, T. (2003) Glucocorticoids up-regulate leukotriene B4 receptor-1 expression during neutrophilic differentiation of HL-60 cells. Biochem. Biophys. Res. Commun. 309, 114-9
  218. Taniguchi, T. and Shimizu, T. (2003) Characterization of a novel member of murine semaphorin family. Biochem. Biophys. Res. Commun. 30, 242-248
  219. Rijneveld, A.W., Weijer, S., Florquin, S., Speelman, P., Shimizu, T., Ishii, S., and van der Poll, T. (2004) Platelet activating factor receptor deficient mice have an improved host defense against pneumococcal pneumonia. J. Infect. Dis. 189, 711-716
  220. Tashiro, S., Sumi, T., Uozumi, N., Shimizu, T., and Nakamura, T. (2004) B-Myb-dependent regulation of c-Myc expression by cytosolic phospholipase A2 J. Biol. Chem. 279, 17715-17722
  221. Takai, D., Nagase, T., and Shimizu, T. (2004)  New therapeutic key for cystic fibrosis:  a role for lipoxins. Nature Immunol. (News and Views) 5, 357-358
  222. Hori, T., Yokomizo, T., Ago, H., Sugahara, M., Ueno, G., Yamamoto, M., Kumasaka, T., Shimizu, T. and Miyano, M. (2004) Structural basis of leukotriene B4 12-hydroxydehydrogenase/15-oxo-prostaglandin 13-reductase catalytic mechanism and a possible SH3 binding loop. J. Biol. Chem. 279, 22615-22623
  223. Ishii, S., Nagase, T., Shindou, H., Takizawa, H., Ouchi, Y., and Shimizu, T. (2004) Platelet-activating factor receptor develops airway hyperresponsiveness independently of airway inflammation in a murine asthma model. J. Immunol. 172, 7095-7102
  224. Hikiji, H., Ishii, S., Shindou, H., Takato, T., and Shimizu, T. (2004) Absence of platelet-activating factor receptor protects mice from osteoporosis following ovariectomy. J. Clin. Invest. 114, 85-93
  225. Murakami, N., Yokomizo, T., Okuno, T., and Shimizu, T. (2004) G2A is a proton-sensing G-protein coupled receptor antagonized by lysophosphatidylcholine. J. Biol. Chem. 279, 42484-42491
  226. Angeli, V, Llordra, J., Rong, J. X., Satoh, K., Ishii, S., Shimizu, T., Fisher, E, A., and Randolph, G. J. (2004) Dyslipidemia associated with atherosclerotic disease systemically alters dendritic cell mobilization. Immunity 21, 561-574
  227. Ishikawa, S, Uozumi, N., Shiibashi, T, Izumi, T., Fukayama, M, Shimizu, T., Watanbabe, J., and Nogami, S. (2004) Lethal malaria in cytosolic phospholipase A2- and phospholipase IIA-deficient mice. Amer. J. Tropical Med Hyg. 70, 645-650
  228. Houjou, T, Yamatani, K., Nakanishi, H., Imagawa, M., Shimizu, T., and Taguchi, R. (2004) Rapid and selective identification of molecular species in phosphatidylcholine and sphingomyelin by conditional neutral loss scanning and MS3. Rapid Commun. Mass Spectrom. 18, 3123-3130
  229. Ando, K., Tsuji, E., Ando, Y., Kunitomo, J., Yamashita, M., Ohta, S., Nabe, T., Kohno, S., Yokomizo, T., Shimizu, T., and Ohishi, Y. (2004) Preparation of 2- and 4-(2-alkylcarbamoyl-1-methylvinyl)-7-alkyloxybenzo[b]furans having potent antagonistic activity against human leukotriene B4 BLT1 and/or BLT2 receptors. Org. Biomol. Chem. 2, 3427-3431
  230. Branger, J., Wieland, C. W., Florquin, S., Maris, N. A., Pater, J. M., Speelman, P., Shimizu, T., Ishii, S., van der Poll, T. (2004) Platelet-activating factor receptor deficient mice show an unaltered clearance of Haemophilus influenzae from their respiratory tract. Shock 22, 543-547
  231. Houjou, T., Yamatani, K., Imagawa, M, Shimizu, T., and Taguchi, R. (2005) A shotgun tandem mass spectrometric analysis of hospholipids with normal-phase and/or reverse-phase liquid chromtography/electrospray ionization mass spectrometry. Rapid Commun. Mass Spectrom. 19, 654-666
  232. Lang, P. A., Kempe, D. S., Tanneur, V., Eisele, K., Klarl, B.A., Myssina, S., Jendrossek, V., Ishii, S., Shimizu, T., Waidmann, M., Hessler, G., Huber, S. M., Lang, F., and Wieder, T. (2005) Stimulation of erythrocyte ceramide formation by platelet activating factor. J. Cell Sci. 118, 1233-1243
  233. Ishii, S., Kihara, Y., and Shimizu, T. (2005) Identification of T cell death-associated gene 8 (TDAG8) as a novel acid sensing G-protein-coupled receptor. J. Biol. Chem. 280, 9083-9087
  234. Shimada, A., Satoh, M., Chiba, Y., Saitoh, Y., Kawamura, N., Keino, H., Hosokawa, M., and Shimizu, T. (2005) Highly selective localization of leukotriene C4 synthase in hypothalamic and extrahypothalamic vasopressin systems of mouse brain. Neurosci. 131, 683-689
  235. Kita, Y., Takahashi, T., Uozumi, N., Nallan, L., Gelb, M. H., and Shimizu, T. (2005) Pathway-oriented profiling of lipid mediators in macrophages. Biochem. Biophys. Res. Commun. 330, 898-906
  236. Ishida, M., Imagawa, M., Shimizu, T., and Taguchi, R. (2005) Specific detection oflysphosphatidic acids in serum extracts by tandem mass spectrometry. J. Mass Spectrom. Soc. Jpn. 53, 25-32
  237. Saiga, A., Uozumi, N., Ono, T., Seno, K., Ishimoto, Y., Arita, H., Shimizu, T., and Hanasaki, K. (2005) Group X secretory phospholipase A2 can induce arachidonic acid release and eicosanoid production without activation of cytosolic phospholipase A2. Prostaglandins Other Lipid Med. 75, 79-89
  238. Fahy, E., Subramaniam, S., Brown, A., Glass, C.K., Merrill, A.H., Jr., Murphy, R.C., Raetz, E.R.H., Russell, D.W., Seyama, Y., Shaw, W., Shimizu, T., Spener, F., van Meer, G., VanNieuwenhze, M.S., Stephen H. White, S.H., Witztum, J.L., and Dennis, E.A. (2005) A comprehensive classification system for lipids J. Lipid Res. 46, 839-862
  239. Ando, K., Tsuji, E., Ando, Y., Kunitomo, J., Kobayashi, R., Yokomizo, T., Shimizu, T., Yamashita, M., Ohta, S., Nabe, T., Kohno, S., and Ohishi, Y. (2005) Synthesis of 2-, 4- and 5-(2-alkylcarbamoyl-1-methylvinyl)-7-alkyloxybenzo[b]furans and their leukotriene B(4) receptor antagonistic activity. Org. Biomol. Chem. 3, 2129-2139
  240. Kita, Y., Takahashi, T., Uozumi, N., and Shimizu, T. (2005) A multiplex quantitation method for eicosanoids and platelet-activating factor using column-switching reversed-phase liquid chromatography-tandem mass spectrometry. Anal. Biochem. 342, 134-143
  241. Ohto, T., Uozumi, N., Hirabayashi, T., and Shimizu, T. (2005) Identification of novel cytosolic phospholipase A2s, murine cPLA2 delta, epsilon, and zeta, which form a gene cluster with cPLA2 beta. J. Biol. Chem. 280, 24576-24583
  242. Iizuka, Y., Yokomizo, T., Terawaki, K., Komine, M., Tamaki, K., and Shimizu, T. (2005) Characterization of a mouse second leukotriene B4 receptor, mBLT2. J. Biol. Chem. 280, 24816-24823
  243. Shindou, H., Ishii, S., Yamamoto, M., Takeda, K., Akira, S., and Shimizu, T. (2005) Priming effect of lipopolysaccharide on acetyl-CoA:lyso-PAF acetyltransferase is MyD88 and TRIF-independent. J. Immunol. 175, 1177-1183
  244. Taniguchi, M., Masuda, T., Fukaya, M., Kataoka, H., Mishina, M., Yaginuma, H., Watanabe, M., and Shimizu, T. (2005) Identification and characterization of a novel member of murine semaphorin family. Genes to Cells 10, 785-792
  245. Marusic, S., Leach, M.W., Pelker, J.W., Azoitei, M.L., Uozumi, N., Cui, J., DeClercq, C.M., Shen, M.W.H., Miyashiro, J.S., Carito, B.A., Thakker, P., Simmons, D.L., Leonard, J.P., Shimizu, T., and Clark, J.D. (2005) Cytosolic phospholipase A2alpha-deficient mice are resistant to experimental autoimmune encephalomyelitis. J. Exp. Med. 202, 841-851
  246. Kihara, Y., Ishii, S., Kita, Y., Toda, A., Shimada, A., and Shimizu, T. (2005) Dual phase regulation of experimental allergic encephalomyelitis by platelet-activating factor. J. Exp. Med. 202, 853-863
  247. Oikawa, Y., Yamato, E., Tashiro, F., Yamamoto, M., Uozumi, N., Shimada, A., Shimizu, T., and Miyazaki, J. (2005) Protective role for cytosolic phospholipase A2alpha in autoimmune diabetes of mice. FEBS Lett. 579, 3975-3978
  248. Zhang, Q., Mousdicas, N., Yi, Q., Al-Hassani, M., Billings, S. D., Perkins, S. M., Howard, K. M., Ishii, S., Shimizu, T., and Travers, J. B. (2005) Staphylococcal lipoteichoic acid inhibits delayed-type hypersensitivity reactions via the platelet-activating factor receptor. J. Clin. Invest. 115, 2855-2861
  249. Terawaki, K., Yokomizo, T., Nagase, T., Toda, A., Taniguchi, M., Hashizume, K., Yagi, T., and Shimizu, T. (2005) Absence of leukotriene B4 receptor 1 confers resistance to airway hyperresponsiveness and Th2 type immune responses. J. Immunol. 175, 4217-4225
  250. Toyo-oka, K., Sasaki, S., Yano, Y., Mori, D., Kobayashi, T., Toyoshima, Y. Y., Tokuoka, S. M., Ishii, S., Shimizu, T., Muramatsu, M., Hiraiwa, N., Yoshiki, A., Wynshaw-Boris, A., and Hirotsune, S. (2005) Recruitment of katanin p60 by phosphorylated NDEL1, a LIS1 interacting protein, is essential for mitotic cell division and neuronal migration. Hum. Mol. Genet. 14, 3113-3128
  251. van der Sluijs, K. F., van Elden, L. J. R., Nijhuis, M., Schuurman, R., lorquin, S., Shimizu, T., Ishii, S., Jansen, H. M., Lutter, R., and van der Poll, T. (2006) Involvement of the platelet activating factor receptor in host defense against Streptococcus pneumoniae during postinfluenza pneumonia. Am. J. Physiol. 290, L194-L199
  252. Doi, K., Okamoto, K., Negishi, K., Suzuki, Y., Nakao, A., Fujita, T., Toda, A., Yokomizo, T., Kita, Y., Kihara, Y., Ishii, S., Shimizu, T., and Noiri, E. (2006) Attenuation of folic acid-induced renal inflammatory injury in platelet-activating factor receptor-deficient mice. Am. J. Pathol. 168, 1413-1424
  253. Yoshikawa, K., Kita, Y., Kishimoto, K., and Shimizu, T. (2006) Profiling of eicosanoid production in the rat hippocampus during kainate-induced seizure: Dual-phase regulation and differential involvement of cox-1 and cox-2. J. Biol. Chem. 281, 14663-14669
  254. Nakanishi, H., Shindou, H., Hishikawa, D., Harayama, T., Ogasawara, R., Suwabe, A., Taguchi, R., and Shimizu, T. (2006) Cloning and characterization of mouse lung-type acyl-coa:lysophosphatidylcholine acyltransferase 1 (LPCAT1): Expression in alveolar type II cells, and possible involvement in surfactant production. J. Biol. Chem. 281, 20140-20147
  255. Chiba, Y., Shimada, A., Satoh, M., Saitoh, Y., Kawamura, N., Hanai, A., Keino, H., Ide, Y., Shimizu, T., and Hosokawa, M. (2006) Sensory system-predominant distribution of leukotriene a(4) hydrolase and its colocalization with calretinin in the mouse nervous system. Neurosci. 141, 917-927
  256. Kita, Y., Ohto, T., Uozumi, N., and Shimizu, T. (2006) Biochemical properties and pathophysiological roles of cytosolic phospholipase A2s. Biochim. Biophys. Acta 1761, 1317-1322
  257. Akiba, S., Mukaida, Y., Hane, K., Oka, M., Uozumi, N., Shimizu, T., and Sato, T. (2006) Group IVA phospholipase A(2)-mediated production of fibronectin by oxidized LDL in mesangial cells. Kidney Int. 70, 1013-1018
  258. Schaefer, M. B., Ott, J., Mohr, A., Bi, M. H., Grosz, A., Weissmann, N., Ishii, S., Grimminger, F., Seeger, W., and Mayer, K. (2007) Immunomodulation by n-3- vs. n-6-rich lipid emulsions in murine acute lung injury - role of platelet-activating factor receptor. Crit. Care Med. 35, 544-554
  259. Yanagida, K., Ishii, S., Hamano, F., Noguchi, K., and Shimizu, T. (2007) LPA4/p2y9/GPR23 mediates Rho-dependent morphological changes in a rat neuronal cell line. J. Biol. Chem. 282, 5814-5824
  260. Shindou, H., Hishikawa, D., Nakanishi, H., Harayama, T., Ishii, S., Taguchi, R., and Shimizu, T. (2007) A single enzyme catalyzes both PAF production and membrane biogenesis of inflammatory cells: cloning and characterization of acetyl-CoA:lyso-PAF acetyltransferase. J. Biol. Chem. 282, 6532-6539
  261. Kuniyeda, K., Okuno, T., Terawaki, K., Miyano, M., Yokomizo, T., and Shimizu, T. (2007) Identification of the intracellular region of the Leukotriene B4 receptor type-1 that specifically involves in Gi-activation. J. Biol. Chem. 282, 3998-4006
  262. Tsuda, M., Ishii, S., Masuda, T., Hasegawa, S., Nakamura, K., Nagata, K., Yamashita, T., Furue, H., Tozaki-Saito, H., Yoshimura, M., Koizumi, S., Shimizu, T., and Inoue, K. (2007) Reduced pain behaviors and ERK activation in primary sensory neurons by peripheral tissue injury in mice lacking platelet-activating factor receptor. J. Neurochem. 102, 1658-1668
  263. Kitaura, H., Uozumi, N., Tohmi, M., Yamazaki, M., Sakimura, K., Kudoh, M., Shimizu, T., and Shibuki, K. (2007) Roles of nitric oxide as a vasodilator in neurovascular coupling of mouse somatosensory cortex. Neurosci. Res. 59, 160-171
  264. Li, Y., Yamada, H., Kita, Y., Kunimi, M., Horita. S., Suzuki, M., Endo, Y., Shimizu, T., Seki, G., and Fujita, T. (2007) Roles of ERK and group IVA cytosolic PLA2 in biphasic regulation of renal proximal transport by angiotensin II. J. Amer. Soc. Nephrol. 19, 252-259
  265. Kimura, M., Taniguchi, M., Mikami, Y., Masuda, T., Yoshida, T., Mishina, M., and Shimizu, T. (2007) Identification and characterization of zebrafish semaphorine 6D. Biochem. Biophys. Res. Commun. 363, 762-768
  266. Hishikawa, D*., Shindou, H*. (*, equal contribution), Kobayashi, S., Nakanishi, H., Taguchi, R., and Shimizu, T. (2008) Discovery of a lysophospholipid acyltransferase family essential for membrane asymmetry and diversity. Proc. Natl. Acad. Sci. USA 105, 2830-2835
  267. Harayama, T*., Shindou, H*. (*, equal contribution), Ogasawara, R., Suwabe, A, and Shimizu, T. (2008) Identification of a novel non-inflammatory biosynthetic pathway of platelet-activating factor. J. Biol. Chem. 283, 11097-11106
  268. Tsujimura, Y., Obata, K., Mukai, K., Shindou, H., Yoshida, M., Nshikado, H., Kawano, Y., Minegishi, Y., Shimizu, T., and Karasuyama, H. (2008) Basophils play a pivotal role in IgG-, but not IgE-mediated systemic anaphylaxis in contrast to mast cells. Immunity 28, 581-589
  269. Okuno, T., Iizuka, Y., Okazaki, H., Yokomizo, T., Taguchi, R., and Shimizu, T. (2008) 12(S)-Hydroxyheptadeca-5Z, 8E, 10E-trienoic acid is a natural ligand for leukotriene B4 receptor 2. J. Exp. Med. 205, 759-766
  270. Jiang, W., Hall, S. R., Moos, M. P. W., Cao, R. Y., Ishii, S., Ogunyankin, K. O., Melo, L. G., and Funk, C. D.(2008) Endothelial cysteinyl leukotriene 2 receptor (CysLT2R) expression mediates myocardial ischemia-reperfusion injury. Am. J. Pathol. 172, 592-602
  271. Hase, M., Yokomizo, T., Shimizu, T., and Nakamura, M. (2008) Characterization of an orphan G protein-coupled receptor, GPR20, that constitutively activates Gi proteins. J. Biol. Chem. 283, 12747-12755
  272. Ito, S., Ito, Y., Katagiri, H., Suzuki, T., Hoka, S., Yokomizo, T., Shimizu, T., and Majima, M. (2008) Leukotriene B4/Leukotriene B4 Receptor Pathway Is Involved in Hepatic Microcirculatory Dysfunction Elicited by Endotoxin. Shock 30, 87-91
  273. Mashimo, M., Hirabayashi, T., Murayama, T., and Shimizu, T. (2008) Cytosolic PLA2a activation in Purkinje neurons and its role in AMPA-receptor trafficking J. Cell Sci. 121, 3015-3024
  274. Uozumi, N., Kita, Y., and Shimizu, T. (2008) Modulation of lipid and protein mediators of inflammation by cytosolic phospholipase A2alpha during experimental sepsis. J. Immunol. 181, 3558-3566
  275. Kihara, Y., Yanagida, K., Masago, K., Kita, Y., Hishikawa, D., Shindou, H., Ishii, S., and Shimizu, T. (2008) Platelet-Activating Factor Production in the Spinal Cord of Experimental Allergic Encephalomyelitis Mice via the Group IVA Cytosolic PLA2-LysoPAFAT Axis. J. Immunol. 181, 5008-5014
  276. Moos, M. P. W., Mewburn, J. D., Kan, F. W. K., Ishii, S., Abe, M., Sakimura, K., Noguchi, K., Shimizu, T., and Funk, C. D. (2008) Cysteinyl leukotriene 2 receptor-mediated vascular permeability via transendothelial vesicle transport. FASEB J. 22, 4352-4362
  277. Ikeda, K., Shimizu, T., and Taguchi, R. (2008) Targeted analysis of ganglioside and sulfatide molecular species by LC/ESI-MS/MS with theoretically expanded multiple reaction monitoring. J. Lipid Res. 49, 2678-2689
  278. Lopes-Vales, R., Navarro, X., Shimizu, T.., Baskakis, C., Kokotos, G., Constanious-Kokotou, V., Stephen, D., Dennis, E. A., and David, S. (2008) Intracellular phospholipase A2 group IVA and group VIA play important roles in Wallerian degeneration and axon regeneration after peripheral nerve injury. Brain 131, 2620-2631
  279. Li, Y., Yamada, H., Kita, Y., Suzuki, M., Endo, Y., Horita, S., Yamazaki, O., Shimizu, T., Seki, G., and Fujita, T. (2008) Arachidonic acid metabolites inhibit the stimulatory effect of angiotensin II in renal proximal tubules. Hypertens. Res. 31, 2155-2164
  280. Prevost, N., Mitsios, J., Kato, H., Burke, J. E., Dennis, E.A., Shimizu, T. and Shattil, S. J. (2008) Group IVA cytosolic phospholipase A2 (cPLA2) and integrin a IIbb3 reinforce each other's functions during IIb3 signaling in platelets. Blood 113, 447-457
  281. Yasuda, D., Okuno, T., Yokomizo, T., Hori, T., Hirota, N., Hashidate, T., Miyano, M., Shimizu, T., and Nakamura, M. (2009) Helix 8 of leukotriene B4 type-2 receptor is required for the folding to pass the ER quality control. FASEB J. 23, 1470-1481
  282. Yuki, K., Shindou, H., Hishikawa, D., and Shimizu, T. (2009) Characterization of mouse lysophosphatidic acid acyltransferase 3: An enzyme with dual functions in the testis. J. Lipid Res. 50, 860-869
  283. Shindou, H., Eto, M., Morimoto, R., and Shimizu, T. (2009) Identification of membrane O-acyltransferase family motifs. Biochem. Biophys. Res. Commun. 383, 320-325
  284. Harayama, T., Shindou, H., and Shimizu, T. (2009) Biosynthesis of phosphatidylcholine by human lysophosphatidylcholine acyltransferase 1. J. Lipid Res. 50, 1824-1831
  285. Yanagida, K., Masago, K., Nakanishi, H., Kihara, Y., Hamano, F., Tajima, Y., Taguchi, R., Shimizu T., and Ishii, S. (2009) Identification and characterization of a novel lysophosphatidic acid receptor, p2y5/LPA6. J. Biol. Chem. 284, 17731-17741
  286. Murakami, N., Hashidate, T., Harayama, T., Yokomizo, T., Shimizu, T., and Nakamura, M. (2009) Transcriptional regulation of human G2A in monocytes/macrophages : involvement of c/EBPs, Runx and Pu.1. Genes Cells 14, 1441-1455
  287. Matsumoto, T., Inoue, H., Sato, Y., Kita, Y., Nakano, T., Noda, N., Eguchi-Tsuda, M., Moriwaki, A., Kan-O, K., Matsumoto, K., Shimizu, T., Nagasawa, H., Sakuda, S., and Nakanishi, Y. (2009) Demethylallosamidin, a chitinase inhibitor, suppresses airway inflammation and hyperresponsiveness. Biochem. Biophys. Res. Commun. 390, 103-108
  288. Hikiji, H., Ishii, S., Yokomizo, T., Takato, T., and Shimizu, T. (2009) A distinctive role of the leukotriene B4 receptor BLT1 in osteoclastic activity during bone loss. Proc. Natl. Acad. Sci. U. S. A. 106, 21294-21299
  289. Kihara, Y., Matsushita, T., Kita, Y., Uematsu, S., Akira, S., Kira, J.-i., Ishii, S., and Shimizu, T. (2009) Targeted lipidomics reveals mPGES-1-PGE2 as a therapeutic target for multiple sclerosis. Proc. Natl. Acad. Sci. U. S. A. 106, 21807-21812
  290. Oga, T., Matsuoka, T., Yao, C., Nonomura, K., Kitaoka, S., Sakata, D., Kita, Y., Tanizawa, K., Taguchi, Y., Chin, K., Mishima ,M., Shimizu, T., and Narumiya, S. (2009) Prostaglandin F2alpha receptor signaling facilitates bleomycin-induced pulmonary fibrosis independently of transforming growth factor-beta. Nature Med. 12, 1426-1430

Review Articles and Chapters of Books

  1. Hayaishi, O., and Shimizu, T.: Prostaglandin D2, a neuromodulator. in New Horizons in Biological Chemistry (Koike, M., Nagatsu, T., Okuda, J. and Ozawa, T. eds.) Jap. Sci. Soc. Press, Tokyo, pp. 217-219 (1980)
  2. Hayaishi, O., and Shimizu, T.: Metabolic and functional significance of prostaglandins in lipid peroxide research. in Lipid Peroxide in Biology and Medicine. (Yagi, K. ed.), Academic Press, New York, pp 41-53 (1982)
  3. Hayaishi, O., Watanabe, T., Yamashita, A., Ogorochi, T., Narumiya, S., and Shimizu, T.: Antithrombotic action of prostaglandins: Different roles of prostacyclin and PGD2. Advances Pharmacol. Therap. II. 4: 251-260 (1982)
  4. Shimizu, T., Yamamoto, S., and Hayaishi, O. Purification of prostaglandin H-D isomerase from rat brain. Methods Enzymol. 86: 73-77 (1982)
  5. Shimizu, T., Watanabe, K., Tokumoto, H., and Hayaishi, O.: Isolation of NADP-dependent PGD2-specific 15-hydroxyprostaglandin dehydrogenase from swine brain. Methods Enzymol. 86: 147-152 (1982)
  6. Shimizu, T.: Prostaglandin D2 in the nervous system. in Pharmacologic and Biochemical Aspects of Neurotransmitter Receptors. (Yoshida, H., and Yamamura, H. I. eds.) pp 253-266, John Wily and Sons, Inc. New York (1983)
  7. Shimizu, T: Enzymes functional in the syntheses of leukotrienes and related compounds. Int. J. Biochem. 20, 661-666 (1988)
  8. Asano, T., Watanabe, T., Takakura, K., Sano, K and Shimizu, T: Activation of the lipoxygenase pathway following subarachnoid hemorrhage: Relevance to cerebral vasospasm. in Cerebral Vasospasm (R. H. Wilkins ed.) pp. 297-302, Raven Press, NY. (1988)
  9. Sasaki, T., Nakagomi, T., Noguchi, M., Saito, I., Takakura, K., Shimizu, T., and Sawada, M: Topography of prostaglandin synthesis in ischemic brain. in Medical, Biochemical and Chemical Aspects of Free Radicals (Hayaishi, O., Niki, E., Kondo, M., and Yoshikawa, T. eds.) pp 1081-1087, Elsevier, Amsterdam, (1989)
  10. Watanabe, T., Nishiyama, M., Okamoto, H., Hori, T., Asano, T., Masayasu, H., and Shimizu, T: Effects of Ebselen on Experimental Cerebral Vasospasm. in Selenium in Biology and Medicine (Wendel, A. ed.) pp. 177-184, Springer-Verlag (1989)
  11. Watanabe, T., Nishiyama, M., Okamoto, H., Hori, T., Asano, T., Sasaki, T., Takakura, K., and Shimizu, T.: 12-Hydroperoxyeicosatetraenoic acid caused delayed cerebral vasospasm. in Cerebral Vasospasm (Sano, K., Takakura, K., Kassell, N. F., and Sasaki, T. eds.) pp. 134-136, University of Tokyo Press, Tokyo (1990)
  12. Shimizu, T., Honda, Z., Miki, I., Seyama, Y., Izumi, T., Radmark, O., and Samuelsson, B: Potato lipoxygenase: Purification, characterization and preparation of 5(S)-hydroperoxyeicosatetraenoic acid. Methods Enzymol. 187 296-306 (1990)
  13. Ohishi, N., Izumi, T., Seyama, Y., and Shimizu, T.: Purification and characterization of leukotriene A4 hydrolase from human lung. Methods Enzymol. 187 289-296 (1990)
  14. Radmark, O., Funk, C., Fu, J-Y., Matsumoto, T., Jornvall, H., Samuelsson, B., Minami, M., Ohno, S., Kawasaki, H., Seyama, Y., Suzuki, K., and Shimizu, T.: Cloning of leukotriene A4 hydrolase cDNA. Methods Enzymol. 187 486-491 (1990)
  15. Shimizu, T., and Wolfe, L. S: Arachidonic acid cascade and signal transduction. J. Neurochem. 55 1-15 (1990)
  16. Watanabe, T., Asano, T., and Shimizu, T: Arachidonic acid lipoxygenase products participate in the pathogenesis of delayed cerebral ischemia. in Neurochemical Correlates of Cerebral Ischemia (Bazan, N. G. ed.)pp 45-58, Elsevier, Amsterdam (1990)
  17. Shimizu, T., Izumi, T., Honda, Z., Seyama, Y., Kurachi, Y., and Sugimoto, H: Biosynthesis and functions of leukotriene C4. Advances Prostaglandin, Thromboxane, Leukotriene Res. 20 46-53 (1990)
  18. Watanabe, T., Nishiyama, M., Okamoto, H., Hori, T., Asano, T., Sasaki, T., Takakura, K., Shimizu, T and Seyama, Y (1991) 12-Hydroperoxyeicosatetraenoic acid caused delayed cerebral vasospasm. in Proceedings of the International Conference on Cerebral Vasospasm 1990 pp. 24-26
  19. Shimizu, T. (1992) Molecular cloning of Platelet-Activating Factor receptor. in PAF Receptor Signal Transduction (Shkula, S. D. ed.) pp. 29-40, CRC Press, FL
  20. Shimizu, T, Honda, Z., Nakamura, M., Bito, H., and Izumi, T. (1992) Platelet-activating factor receptor and signal transduction. Biochem. Pharmacol.44, 1001-1008
  21. Watanabe, T., Asano, T., and Shimizu, T. (1992) Arachidonic acid lipoxygenase products participate in the pathogenesis of delayed cerebral ischemia. in Neurochemical Correlates of Cerebral Ischemia, Advances in Neurochemistry 7, pp. 139-159
  22. Izumi, T., and Shimizu, T. (1992) Biosynthesis of leukotriene C4. in Frontier and New Horizons in Amino Acid Research. (Takai, K. ed.) pp. 583-586, Elsevier Science Publishers BV, Amsterdam.
  23. Honda, Z., and Shimizu, T. (1993) Lipid mediators in defense mechanisms. in The Natural Immune System. Humoral Factors. (Sim, E. ed.) pp. 337-367 IRL Press at Oxford University Press, Oxford
  24. Shimizu, T., Minami, M., Sawada, Y., and Izumi, T. (1993) Bifunctional role of leukotriene A4 hydrolase. in Advances in Polyunsaturated Fatty Acid Research (Yasugi, T., Nakamura, H., and Soma, M. eds.) pp. 31-34, Excerpta Medica, Amsterdam
  25. Nakamura, M., Honda, Z., Matsumoto, T., Noma, M., and Shimizu, T. (1993) Isolation and properties of platelet-activating factor receptor cDNAs. J. Lipid Mediat. 6, 163-168
  26. Izumi, T., Minami, M., Ohishi, N., Bito, H., and Shimizu, T. (1993) Site-directed mutagenesis of leukotriene A4 hydrolase: distinction of leukotriene A4 hydrolase and aminopeptidase activities. J. Lipid Mediat. 6, 53-58
  27. Shimizu, T., Mutoh, H. Waga, I., Nakamura, M., Honda, Z., and Izumi, T. (1994) Structure and function of platelet-activating factor receptor. in Molecular Basis of Inflammation. (Navarro, J. ed.) pp. 163-167, Ares-Serono Symposia Publications, Rome
  28. 25. Izumi, T., and Shimizu, T. (1995) Platelet-activating factor receptor: gene expression and signal transduction. Biochim. Biophys. Acta 1259, 317-333
  29. Izumi, T., Honda, Z., Mutoh, H., Kume, K., and Shimizu, T. (1995) Regulation and signal transduction of PAF receptor. Adv. Prostaglandin Thromboxane Leukot. Res. 23, 461-466
  30. Yokomizo, T., Uozumi, N., Takahashi, T., Kume, K., Izumi, T., and Shimizu, T. (1995) Leukotriene A4 hydrolase and leukotriene B4 metabolism. J. Lipid Mediat. Cell Signal 12, 321-332
  31. Yokomizo, T., Ogawa, Y., Uozumi, N., Kume, K., Izumi, T., and Shimizu, T. (1997) cDNA cloning and mutagenesis study of leukotriene B4 12-hydroxy-dehydrogenease. Eicosanoid and Other Bioactive Lipids in Cancer Inflammation and Radiation Injury 3, 151-156
  32. Shimizu, T., and Mutoh, H. (1997) Structure and regulation of platelet activating factor receptor gene. Eicosanoid and Other Bioactive Lipids in Cancer Inflammation and Radiation Injury 3, 197-204
  33. Bito, H., and Shimizu, T. (1997) Molecular characterization and physiological functions of PAF receptor. Eicosanoid and Other Bioactive Lipids in Cancer Inflammation and Radiation Injury 3, 215-221
  34. Ishii, S., Nakamura, M., Waga, I., Kume, K., Izumi, T., and Shimizu, T. (1997) Cloning and characterization of a murine platelet-activating factor gene. Eicosanoid and Other Bioactive Lipids in Cancer Inflammation and Radiation Injury 3, 347-355
  35. Yokomizo, T., Ogawa, Y., Uozumi, N., Kume, K., Izumi, T., and Shimizu, T. (1997) cDNA cloning and mutagenesis study of leukotriene B4 12-hydroxydehydrogenase. Adv. Exp. Med. Biol. 407, 151-156
  36. Shimizu, T., and Mutoh, H. (1997) Structure and regulation of platelet activating factor receptor gene. Adv. Exp. Med. Biol. 407, 197-204
  37. Mori, M., Aihara, M., Kume, K., Hamanoue, M., Kohsaka, S., and Shimizu, T. (1997) Localization of platelet-activating factor receptor in the rat brain. Adv. Exp. Med. Biol. 407, 357-363
  38. Ishii, S., Nakamura, M., Waga, I., Kume, K., Izumi, T., and Shimizu, T. (1997) Cloning and characterization of a murine platelet-activating factor receptor gene. Adv. Exp. Med. Biol. 407, 347-355
  39. Shimizu, T., Yokomizo, T., and Izumi, T. Leukotriene B4 receptor and signal transduction. (2000) Ernst Schering Research Foundation-Workshop 31, Serhan, CN, Perez, A eds. 125-141
  40. Ishii, S., and Shimizu, T. (2000) Platelet-activating factor (PAF) receptor and genetically engineered PAF receptor mutant mice. Prog. Lipid Res. 39, 41-82
  41. Yokomizo, T., Izumi, T., and Shimizu, T. (2001) Leukotriene B4:metabolism and signal transduction. (Review) Arch. Biochem. Biophys. 385, p231-241
  42. Shimizu, T. (2002) Leukotriene receptors. in Wiley Encyclopedia of Molecular Medicine, Vol. 5, pp. 1920-1921, John Wiley & Sons, Inc.
  43. Izumi, T., Yokomizo, T., Obinata, H., Ogasawara, H., Shimizu, T. (2002) Leukotriene receptors: classification, gene expression, and signal transduction. J. Biochem. 132,1-6
  44. Ishii, S., Nagase, T., and Shimizu, T. (2002) Platelet-activating factor receptor. Prostaglandins Other Lipid Mediat. 68-69, 599-609
  45. Toda A, Yokomizo T, Shimizu T. (2002) Leukotriene B4 receptors. Prostaglandins Other Lipid Mediat. 68-69:575-85
  46. Wong, D. A., Uozumi, N., Kita, Y., and Shimizu, T. (2003) Cytosolic phospholipase A2a in mouse platelets: Clinical andtherapeutic implications. Advances in Prostaglandin,Leukotriene and Other Bioactive Lipid Research. (Yazici, Z. Folco,G, C., Drazen, J. M., Niigam, S., and Shimizu, T. eds) pp 81-86, Kluwer Academic/Plenum Publishers, New York. :ISBN: 0306477637
  47. Shimizu, T., Yokomizo, T., and Izumi, T. (2003) Characterizationof two distinct types of leukotriene B4 receptors. Oxygen and Life: Oxygenases, Oxidase, and Lipid Mediators (Ishimura, Y.,Nozaki, M. Yamamoto, S., Shimizu, T., Narumiya, S., and Mitani, F.eds) pp 415-420, Elsevier, Amsterdam. :ISBN: 0444508724
  48. Brink, C., Dahlen, S.E., Drazen, J., Evans, J.F., Hay, D.W.P., Nicosia, S., Serhan, C.N., Shimizu, T., and Yokomizo, T. (2003) Classification of Leukotriene and Lipoxin Receptors: Distribution, Function and Molecular Aspects. Pharmacol. Rev. 55,195-227
  49. Brink, C., Dahlen, S.E., Drazen, J., Evans, J.F., Hay, D.W., Rovati, G.E., Serhan, C.N., Shimizu, T. and Yokomizo, T. (2004) International Union of Pharmacology XLIV. Nomenclature for the Oxoeicosanoid Receptor. Pharmacol. Rev., 56, 149-57
  50. Hirabayashi, T. Murayama, T., and Shimizu, T. (2004) Regulatory mechanism and physiological role of cytosolic phospholipase A2 (review) Biol. Pharm. Bull. 27, 1168-1173
  51. Okuno, T., Yokomizo, T., Hori, T., Miyano, M., and Shimizu, T. (2005) Leukotriene B4 receptor and the function of its helix 8. J. Biol. Chem. 280, 32049-32052
  52. Shimizu, T., Ohto, T., and Kita, Y. (2006) Cytosolic phospholipase A2: Biochemical properties and physiological roles. IUBMB Life 58, 328-333
  53. Taguchi, R., Nishijima, M., and Shimizu, T. (2007) Basic Analytical Systems for Lipidomics by Mass Spectrometry in Japan. Methods Enzymol. 432, 185-211
  54. Hikiji, H., Takato, T., Shimizu, T., and Ishii, S. (2008) The roles of prostanoids, leukotrienes, and platelet-activating factor in bone metabolism and disease. Prog. Lipid Res. 47, 107-126
  55. Shindou H. and Shimizu T. (2009) Acyl-CoA:lysophospholipid acyltransferases. J. Biol. Chem. 284, 1-5
  56. Shimizu, T. (2009) Lipid mediators in health and diseases. Ann. Rev. Pharmacol. Toxicol. 49, 123-150
  57. Shindou, H., Hishikawa, D., Harayama, T., Yuki, K., and Shimizu, T. (2009) Recent progress on Acyl-CoA:lysophospholipid acyltransferase research. J. Lipid Res. 50, S46-S51

Invited Symposia and Plenary Lectures

  1. Shimizu, T., and Izumi, T. Biosynthesis and Function of Leukotriene C4. The 7th International Conference of Prostaglandins and Related Compounds. May 10-15, 1990, Florence
  2. Shimizu, T. Molecular Properties of Platelet-activating Factor Receptor. FASEB Meeting, April 21-25, 1991, Atlanta
  3. Shimizu, T. Arachidonic Acid Cascade. Japanese-German Workshop on Cancer. October 24-26, 1991, Essen
  4. Shimizu, T., and Izumi, T. Platelet-activating Factor Receptor and Signal Transduction. The 3rd International Conference of Eicosanoids and Other Bioactive Lipids. September 21-24, 1991, Berlin
  5. Izumi, T., and Shimizu, T. Biosynthesis of Leukotriene C4. The First Biennial International Conference on Amino Acid Research; Frontiers and New Horizons. August 14-18, 1991, Kyoto
  6. Bito, H., and Shimizu, T. Platelet-activating Factor in the Brain. The 8th International Conference on Prostaglandins and Related Compounds. July 26-31, 1992, Montreal
  7. Izumi, T., Minami, M., Ohishi, N., Bito, H., and Shimizu, T. Site-directed Mutagenesis of Leukotriene A4 Hydrolase. The 8th International Conference on Prostaglandins and Related Compounds. July 26-31, 1992, Montreal
  8. Kume, K., and Shimizu, T. Structure and Function of Platelet-activating Factor Receptor. The 4th International Congress on Platelet-activating Factor and Related Lipid Mediators. September 22-26, 1992, Salt Lake
  9. Shimizu, T., Mutoh, H., Waga, I., Nakamura, M., Honda, Z., and Izumi, T. Structure and Function of Platelet-activating Factor Receptor. Ares-Serono Symposium, April 22-24, 1993, Heidelberg
  10. Shimizu, T. Platelet-activating factor receptor and signal transduction. The New York Academy of Science; Cellular Generation, Transport and Effects of Eicosanoids; November 14-17, 1993, Stockholm
  11. Izumi, T., and Shimizu, T. Molecular Cloning and Signal Transduction of PAF Receptor. International Symposium on Molecular Biology of Arachidonate Cascade. December 6-7, 1993, Kyoto.
  12. Yokomizo, T., and Shimizu, T. Biosynthesis and metabolism of leukotriene B4. International Symposium on Molecular Biology of Arachidonate Cascade. December 6-7, 1993, Kyoto.
  13. Izumi, T., and Shimizu, T. Regulation and Signal Transduction of PAF Receptor. The 9th International Conference on Prostaglandins and Related Compounds. June 6-10, 1994, Florence
  14. Shimizu, T. PAF Receptor and MAP Kinase. Leon Wolfe Neurochemical Symposium May 9-13, 1994, New Orleans
  15. Shimizu, T., Honda, Z., Sakanaka, C., Takano, T., Kume, K., Mutoh, H., Bito, H., Waga, I., Ferby, I., and Izumi, T. MAP kinase activation by platelet-activating factor receptor/G-proteins. 12th International Congress of Pharmacology (IUPHAR), July 24-29, 1994, Montreal
  16. Shimizu, T. Structure and regulation of PAF receptor gene. 1995 Annual Meeting of American Society of Pharmacology and Experimental Therapeutics (ASPET) April 10-15, 1995, Atlanta
  17. Shimizu, T., Mori, M., Aihara, M., Bito, H., Tabuchi, S., and Sakanaka, C. Genes, signal transduction and possible roles of PAF in hippocampal neuron and glia. 15th Biennial Meeting of the International Society for Neurochemistry. July 1-7, 1995, Kyoto. (speaker, and session chair)
  18. Shimizu, T., Bito, H., Mori, M., Sakanaka, C., Aihara, M., Tabuchi, S., and Kume, K. Activation of MAP kinase and arachidonate release by two G-protein-coupled receptor expressed in the rat hippocampus. Satellite Meeting of 15th ISN "Lipid messengers in the nervous system" June 28-30, 1995, Tokyo (speaker, and organizer)
  19. Shimizu, T. (Plenary lecture) PAF receptor-from clone to clinic. Fifth International Congress on Platelet-activating Factor and Related Lipid Mediators. September 12-16, 1995, Berlin
  20. Shimizu, T. Regulation of PAF receptor gene. 2nd International Conference of Inflammation. September 17-22, 1995, Brighton
  21. Shimizu, T. (Plenary lecture) Genes and signal transduction of platelet activating factor receptor. 4th International Conference on Eicosanoid and Other Bioactive Lipids in Cancer, Inflammation and Radiation Injury. October 4-7, 1995, Hong-Kong
  22. Shimizu, T. Lipid messengers in synaptic transmission. 1st France-Japan Workshop on Neurosciences, November 20-21, 1995, Paris
  23. Shimizu, T., Mutoh, H., and Kato, S. Tissue-specific expression of platelet-activating factor receptor gene by different promoter usage. FASEB Conference, June 1-6, 1996, New Orleans
  24. Shimizu, T. Cloning of leukotriene B4 receptors from HL-60 cells. Gordon Research Conference: Biochemistry of Lipids and Lipid Mediators. June 22-27, 1997, Kimball Union Academy, Meriden, NH
  25. Shimizu, T. Lipid mediators; from clone to clinic. The 33rd Annual Southeastern Regional Lipid Conference,　November 4-6, 1998, Cashiers, NC
  26. Shimizu, T. Cloning and characterization of leukotriene B4 receptor. Leukotrienes as targets of asthma and other diseases: current basic and clinical research, November 15-17, 1998, Stockholm
  27. Shimizu, T. A Keynote Address: Biosynthesis and Functions of Lipid Mediators; Keystone Symposia 1999, April 1-7, 1999, Keystone
  28. Shimizu, T. Role of cytosolic phospholipase A2 in vivo. 1st International Conference on phospholipase A2. May 26-29, 1999, Berlin
  29. Shimizu, T. Leukotriene Receptor and Signal Transduction. Ernst Shering Research Foundation Workshop: Advances in Eicosanoid Research, June 28-30, 1999, San Francisco
  30. Shimizu, T. Role of cytosolic phospholipase A2 in vitro and in vivo. The 6th International Conference on Eicosanoid and Other Bioactive Lipids in Cancer, Inflammation and Related Diseases. September 12-15, 1999, Boston.
  31. Shimizu, T., Izumi, T., and Yokomizo, T. Leukotriene B4 receptors: from clone to clinic. The 11th International Conference on Prostaglandin and Leukotriene Research. June 4-8, 2000, Florence.
  32. Shimizu, T. Roles of cytosolic phospholipase A2 and related molecules in vivo. FASEB Summer Research Conference on Phospholipases.July 8-13, 2000, Snowmass Village
  33. Shimizu, T., Uozumi, N., Hirabayashi, T., Shirakawa, J., and Kishimoto, K. Cytosolic phospholipase A2 and related molecules in the brain. (Invited lecture) The 7th International Congress on Platelet-activating Factor and Lipid Mediators. September 24-27, 2001, Tokyo
  34. Shimizu, T. Roles of cytosolic phospholipase A2 in vivo. (Plenary lecture) The 7th International Conference on Eicosanoids and Other Bioactive Lipids in Cancer, Inflammation and Related Diseases. October 14-17, 2001, Vanderbilt, Nashville
  35. Shimizu, T. Advance in Eicosanoid Research (Key lecture) 10th Anniversary of Ernst Schering Research Foundation Workshop. November 23-24, 2001, Berlin
  36. Shimizu, T. Roles of cytosolic phospholipase A2a in vivo. 2002 FASEB Summer Research Conference on Phospholipases, June 28-July 3, 2002, Tuscon, AZ
  37. Shimizu, T., and Uozumi, N. Roles of cytosolic phospholipase A2 in vivo. International Symposium on Recent Biomedical Advances in Eicosanoid Research. August 22-24, 2002, Berlin
  38. Shimizu, T. Cytosolic phospholipase A2 and related molecules (Plenary lecture). 12th International Conference on Advances in Prostaglandin, Leukotriene and Other Bioactive Lipid Research. August 25-29, 2002, Istanbul
  39. Shimizu, T. Metabolism and receptors for leukotrienes and lipid mediators. Keyston Symposia (co-chairman); Eicosanoid lipid mediators. March 11-17, 2003, Granlibakken, Tahoe
  40. Shimizu, T. Lipid mediators from bench to clinic; an expanding field of postgenome research. International Riken Symposium of Structural Biology. January 22-23, 2004, Harima, Japan
  41. Shimizu, T. Lipid mediators in health and diseases. Chancellor's Award lecture of Louisiana State University. May 19, 2004, New Orleans
  42. Shimizu, T. Physiological roles of cPLA2 enzymes. FASEB Summer Research Conferences on Phospholipases. July 17-22, 2004, Callaway, Pine Mountains, GA
  43. Shimizu, T. Roles of cytosolic phospholipase A2s in vitro and in vivo. (Plenary lecture) 2nd International Phospholipase A2/8th International PAF Joint conferences. October 6-10, 2004, Berlin
  44. Shimizu, T. Lysophopholipid/proton sensing receptors FASEB Summer Research Conference on Lysophospholid mediators in health and diseases. June 11-16, 2005, Snowmass, CO
  45. Shimizu, T. Lipid mediators in health and diseases. Pharmacology Seminar at University of California San Diego. September 9th, 2005, La Jolla, CA
  46. Shimizu, T. Cytosolic phospholipase A2: biological significance and molecular diversity. 9th International Conference on Eicosanoids and other Bioactive Lipids in Cancer, Inflammation and Related Diseases. September 11-14, 2005, San Francisco, CA
  47. Shimizu, T. Biochemistry and Biology of Leukotriene B4. Keystone Symposia on Eicosanoids in Inflammation and Chronic Diseases. January 10-15, 2006, Park City, UT
  48. Shimizu, T. Keynote lecture: Biochemical properties and physiological roles o f cytosolic phospholipase A2. 2nd International Conference on Non-mammalian Eicosanoids. May 24-27, 2006, Berlin
  49. Shimizu, T. The eicosanoid cascade: Lipid mediators of chronic inflammation. Days of Molecular Medicine 2006 (organized by Karolinska Institute, MGH and Na ture Medicine). May 24-27, 2006, Stockholm
  50. Shimizu, T. Lipid mediators; fundamental regulators of immune responses and inflammatory reactions. RCAI-JSI International Symposium on Immunology 2006. June 16-18, 2006, Yokohama
  51. Shimizu, T. Roles of lipids and lipid mediators in lung physiology and pathology. Distinguished Seminar Series at National Jewish Medical Research Center-University of Colorado. February 19, 2007, Denver
  52. Shimizu, T. Keynote lecture: Profiling lipid mediators and membrane lipids in various disease models. Keystone Symposia on Bioactive Lipids. February 20-25, 2007, Taos, New Mexico
  53. Shimizu, T. Plenary lecture: Characterization of lyso-PAF acetyltransferase and other lysophospholipid acyltransferases. The 3rd International Conference on Phospholipase A2 and Lipid Mediators. May 9-12, 2007, Sorrento, Italy
  54. Shimizu, T. Phospholipid metabolism and lipid mediators. FASEB Summer Research Conference on Lysophospholipid Mediators. June 9-14, 2007, Tuscon, AZ
  55. Shimizu, T. Phospholipase A2 and lysophospholipid acyltransferases (Lands' cycle). 10th International Conference on Eicosanoids and Lipid Mediators. September 16-20, 2007, Montreal
  56. Shimizu, T. Lipid mediators and lipid metabolism. Keystone Symposia on Eicosanoids in Heath and Diseases. January 7-11, 2008, Park Mountain, Montana

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