Department of Biochemistry and Molecular Biology
Faculty of Medicine, The University of Tokyo
News & Topics
Recent Works
- Cloning and characterization of acetyl-CoA:lyso-PAF acetyltransferase - Shindou et al., J. Biol. Chem. (2006) in press.
- LPA4/p2y9/GPR23 mediates morphological changes of neuronal cell line - Yanagida et al., J. Biol. Chem. (2006) in press.
- LTB4 receptor BLT1 - intracellular region involved in Gi signaling - Kuniyeda et al., J. Biol. Chem. (2006) in press.
- LPCAT1, a lysophospholipid acyltransferase in alveolar type II cells - Nakanishi et al., J. Biol. Chem. (2006)
- Kainate-Induced Eicosanoid Production in Rat Hippocampus - Yoshikawa et al., J. Biol. Chem. (2006)
- PAF in Multiple Sclerosis - Kihara et al., J. Exp. Med. (2005)
- Multiplex Quantification Method for Eicosanoids - Kita et al., Anal. Biochem. (2005)
Arachidonate metabolites (prostaglandins, leukotrienes), phospholipid derivatives (platelet-activating factor, lysophosphatidic acid), lipopolysaccharide (LPS), and lipid-soluble vitamins are bioactive compounds, collectively termed "lipid mediators". These compounds play important roles in self-defense mechanisms and neuronal functions, working in concert with cytokines, neurotransmitters, and hormones. We are currently studying the metabolism and functions of these lipid mediators using strategies of biochemistry, recombinant genetic engineering and mutant mice technologies.
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This website is maintained by Y.Kita - Last Update: 061221
visits since 060122